The information provided is taken from various reference sources. It is provided as a guideline. No responsibility can be taken by the author or the Breastfeeding . Because absorption from the eye is limited, ophthalmic prednisolone would not be expected to cause any adverse effects in breastfed infants. To substantially. I am having a flare up and have been put on 40mg of prednisolone for a week, then 30 for a week and so forth tapering down in 10mgs per. Your dose may go up or down. Secretion of prednisolone into breast milk. An unexpected temporary suppression of lactation after a local corticosteroid injection for tenosynovitis. Thanks so much. Prednisolone and breastfeeding.