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Generic Cytoxan (Cyclophosphamide)
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Cytoxan
Cytoxan is used for treatment of cancer with cytotoxic effect.
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Cytoxan
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Cytoxan
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Talk to your doctor about how you are feeling during your treatment. Drug Class. Talk to your doctor about the risks of using this medication for your condition. Pictured is a woman with microscopic polyangiitis treated with intravenous cyclophosphamide and high doses of corticosteroids. Most of the aldophosphamide is then oxidised by the enzyme aldehyde dehydrogenase ALDH to make carboxycyclophosphamide. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. A small proportion of aldophosphamide freely diffuses into cells, where it is decomposed into two compounds, phosphoramide mustard and acrolein. Drug Class. For example, systemic lupus erythematosus with severe lupus nephritis may respond to pulsed cyclophosphamide. What special precautions should I follow? Use of this Site All information contained within the Johns Hopkins Vasculitis website is intended for educational purposes only. Cyclophosphamide may cause other side effects. However, in studies carried out after the clinical efficacy of cyclophosphamide was demonstrated, phosphoramide mustard proved to be cytotoxic in vitro footnote omittedbut to have a low therapeutic index in vivo. This damage predisposes patients to the development of bladder cancer. The best method of screening for this complication is to check for red blood cells in the urine by performing a urinalysis, followed by cystoscopy if red blood cells are present. Your doctor will determine your exact dosage and schedule. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Oral cyclophosphamide is rapidly absorbed and then converted by mixed-function oxidase enzymes cytochrome P system in the liver to active metabolites. Different drugs may affect different parts of the body. Keep this medication in the container it came in, tightly closed, and out of reach of children. When cyclophosphamide is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. It is often included in pre-transplant chemotherapy. Doxorubicin Trastuzumab Pertuzumab. Your doctor will order certain lab tests to check your body's response to cyclophosphamide. Find a Doctor. Cytoxan cyclophosphamide. Alkylating agents. Due to its toxicity, it is replaced as soon as possible by less toxic drugs. Brand names Other names. Related Articles.

Cytoxan - variant does

However, in studies carried out after the clinical efficacy of cyclophosphamide was demonstrated, phosphoramide mustard proved to be cytotoxic in vitro footnote omittedbut to have a low therapeutic index in vivo. Find a Doctor Search by Specific Doctor. Some of the dosage forms listed on this page may not apply to the brand name Cytoxan. Cyclophosphamide is classified as an alkylating agent. Serious allergic reactions including anaphylaxis are rare. You may get a drug called mesnawhich helps to decrease irritation and bleeding. Narcotic pain medicines may also be yCtoxan for several weeks. The cell cycle goes from Cytoxqn resting phase, through active growing phases, Chtoxan then to mitosis division. Cyclophosphamide pronounced as sye kloe foss' fa mide. Thanks for your feedback! Some side effects may not be reported. What are your concerns? ALDHs protect these actively proliferating tissues against toxic effects Cyoxan phosphoramide mustard and acrolein by converting aldophosphamide to carboxycyclophosphamide that does not give rise Cutoxan the toxic metabolites Cttoxan mustard and acrolein. If you experience symptoms or side effects, be sure to discuss them with your health care team. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Archived from the original on 10 May Meet the team. These side effects may go away during treatment as your body adjusts to the medicine. Drink plenty of fluids while you are using this medication. It is important to void empty your bladder frequently especially in the first 24 hours after taking cyclophosphamide. Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. The bone marrow is the organ of the body that makes red blood cells which carry oxygenwhite blood cells which fight infectionand platelets which help the blood clot. This risk may be dependent on dose and other factors, including the condition, other agents or treatment modalities including radiotherapytreatment length and intensity. The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. Other brands: Cytoxan LyophilizedNeosar. Cyclophosphamide Cttoxan be administered either intravenously approximately once a month or orally once a day, typically in a smaller dose. International Drug Price Cytoxna Guide. Follow all instructions closely. Patients taking oral cyclophosphamide should drink plenty of fluids each day to help prevent problems. Cyclophosphamide cyclophosphamide. For the most part, the potential side—effects of cyclophosphamide differ from those of prednisone. Cyclophosphamide side effects will improve after therapy is complete. If the cells are unable to divide, they die. Cytozan Francaises d'Anesthesie et de Reanimation in French. Precautions Before starting cyclophosphamide treatment, make sure you tell your doctor about any other medications you are taking including prescription, over-the-counter, vitamins, herbal remedies, etc. Phosphoramide mustard, one of the principal toxic metabolites of cyclophosphamide, was synthesized and reported by Friedman and Seligman in [52] …It was postulated that the presence of the phosphate bond to the nitrogen atom could inactivate the nitrogen mustard moiety, but the phosphate bond would be cleaved in gastric cancers and other tumors which had a high phosphamidase content. MESNA appears to neutralize the toxic metabolite of cyclophosphamide acrolein that is thought to be responsible for the bladder complications. These drugs are cell-cycle non-specific. Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. It may take several weeks for symptoms to improve and the full effect may take several months or longer. A year followup study". The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division. The risk of cancer appears to be dependent upon the length of time patients have taken the medication and the cumulative dosage of the drug. About About Drugs. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Common use

Cytoxan belongs to the drugs for treatment of cancer with cytotoxic effect. Its active substance cyclophosphamide is converted in the liver by cytochrome P450 into two active substances acrolein and phosphoramide. They are the active compounds, and they slow the growth of cancer cells inhibiting their proliferation and metabolism. First of all this effect concerns cells of uncontrolled growing but also damages other cells of the body resulting in serious side effects. Cytoxan also can be referred to as immunosuppressive agent. Cytoxan is used to treat malignant lymphoma (lymphocytic and gistiotsitarnaya lymphoma, lymphogranulomatosis, Burkitt lymphoma, lymphoma, mixed type), multiple myeloma, leukemias (lymphocytic leukemia, granulocytic leukemia, myelocytic leukemia, acute lymphoblastic leukemia in children), neuroblastoma, ovarian adenocarcinoma, retinoblastoma, breast carcinoma.



Dosage and direction

For adults and children Cytoxan is administered intravenously by 40-50 mg/kg over 3-5 days in divided doses. An oral dose of this medication is oral dose is 1-5 mg/kg daily. Dosage should be corrected on a basis of regular blood tests for white blood cell count. This medication can be taken orally also with or without food.



Precautions

Carefulness should be exercised in patients with myelosuppression, liver or kidney disorders, with the previous radiation and chemotherapy. During treatment a regular monitoring of blood and urine count tests (for the presence of red blood cells) is required. In women of childbearing age a reliable contraception is recommended if Cytoxan is taken.



Contraindications

Hypersensitivity, severe myelosuppression.



Side effects

Side effects of Cytoxan include vulnerability to infections, the development of a secondary cancer, typically of the bladder, lymph nodes, or bone marrow. A secondary cancer may occur several years after the drug is given.



Drug interaction

Notify your doctor before to take anticancer drugs such as doxorubicin, allopurinol, and phenobarbital with Cytoxan. Correction of steroid hormones dosage should be done if they are taken with Cytoxan in patients with removed adrenal glands.



Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.



Overdose

Symptoms of Cytoxan overdose are not expected. If you suppose that took too much of it call your doctor immediately.



Storage

Store at room temperature between 20-25 C (68-77 F). Keep out of heat, moisture, sunlight, of the reach of children. Storage in a bathroom is not recommended.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. РђРїСѓ specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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